Evidence That a Locus for Familial High Myopia Maps to Chromosome 18p

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A genome wide scan for familial high myopia suggests a novel locus on chromosome 7q36.

High myopia often appears as a familial disease. It is usually defined as a refraction error equal to or below −6 diopters (D) in each eye. Highly myopic patients represent 27-33% of the myopic population. The prevalence of the disease in the general population varies according to the country, from 2.1% in the USA, to 3.2% in France, and up to 9.6% in Spain. High myopia is also termed “patholog...

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New locus for autosomal dominant high myopia maps to the long arm of chromosome 17.

PURPOSE To map the gene(s) associated with autosomal dominant (AD) high-grade myopia. METHODS A multigeneration English/Canadian family with AD severe myopia was ascertained. Myopes were healthy, with no clinical evidence of syndromic disease, anterior segment abnormalities, or glaucoma. The family contained 22 participating members (12 affected). The average age of diagnosis of myopia was 8....

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Familial dilated cardiomyopathy locus maps to chromosome 2q31.

BACKGROUND Inherited gene defects are an important cause of dilated cardiomyopathy. Although the chromosome locations of some defects and 1 disease gene (actin) have been identified, the genetic etiologies of most cases of familial dilated cardiomyopathy remain unknown. METHODS AND RESULTS We clinically evaluated 3 generations of a kindred with autosomal dominant transmission of dilated cardi...

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LETTERS TO JMG A genome wide scan for familial high myopia suggests a novel locus on chromosome 7q36

High myopia often appears as a familial disease. It is usually defined as a refraction error equal to or below −6 diopters (D) in each eye. Highly myopic patients represent 27-33% of the myopic population. The prevalence of the disease in the general population varies according to the country, from 2.1% in the USA, to 3.2% in France, and up to 9.6% in Spain. High myopia is also termed “patholog...

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A new locus for autosomal dominant high myopia maps to 4q22-q27 between D4S1578 and D4S1612.

PURPOSE Myopia is the most common visual problem in the world. High myopia, the extreme form of myopia that can be complicated by retinal detachment and macular degeneration, affects 1%-2% of the general population. The genes responsible for nonsyndromic high myopia have not been identified although several chromosome loci have been suggested. Additional loci for the majority of high myopia, es...

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ژورنال

عنوان ژورنال: The American Journal of Human Genetics

سال: 1998

ISSN: 0002-9297

DOI: 10.1086/301907